Interaction of cardiotonic thiadiazinone derivatives with cardiac troponin C
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چکیده
منابع مشابه
Interaction of bepridil with the cardiac troponin C/troponin I complex.
We have investigated the binding of bepridil to calcium-saturated cardiac troponin C in a cardiac troponin C/troponin I complex. Nuclear magnetic resonance spectroscopy and [(15)N,(2)H]cardiac troponin C permitted the mapping of bepridil-induced amide proton chemical shifts. A single bepridil-binding site in the regulatory domain was found with an affinity constant of approximately 140 microM(-...
متن کاملInteraction between the regulatory domain of cardiac troponin C and the acidosis-resistant cardiac troponin I A162H.
AIMS Ischaemic heart disease is the leading cause of mortality worldwide. Acidosis is the main mediator of ischaemia and shielding against it might be possible. In this study, we characterize the nature of interaction between the regulatory domain of cardiac troponin C and the A162H-substituted cardiac troponin I (cTnI) that confers protection against acidosis. METHODS AND RESULTS We used nuc...
متن کاملThe solution structure of a cardiac troponin C-troponin I-troponin T complex shows a somewhat compact troponin C interacting with an extended troponin I-troponin T component.
We have investigated the structure of the cTnC-cTnI-cTnT(198-298) calcium-saturated, ternary cardiac troponin complex by small-angle scattering with contrast variation. Shape restoration was also applied to the scattering information resulting from the deuterated cTnC subunit, the unlabeled cTnI-cTnT(198-298) subunits, and the entire complex. The experimental results and modeling indicate that ...
متن کاملCa(2+) exchange with troponin C and cardiac muscle dynamics.
Controversy abounds in the cardiac muscle literature over the rate-limiting steps of cardiac muscle contraction and relaxation. However, the idea of a single biochemical mechanism being the all-inclusive rate-limiting step for cardiac muscle contraction and relaxation may be oversimplified. There is ample evidence that Ca(2+) concentration and dynamics, intrinsic cross-bridge properties, and ev...
متن کاملCa exchange with troponin C and cardiac muscle dynamics
Controversy abounds in the cardiac muscle literature over the rate-limiting steps of cardiac muscle contraction and relaxation. However, the idea of a single biochemical mechanism being the all-inclusive rate-limiting step for cardiac muscle contraction and relaxation may be oversimplified. There is ample evidence that Ca2þ concentration and dynamics, intrinsic cross-bridge properties, and even...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1996
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)84411-3